Quetiapine EP Impurity S HCl CAS 329216-63-9 (free base)
| CAS No. | 329216-63-9 (free base) |
| Molecular Formula | C21H25N3O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Quetiapine EP Impurity S HCl (CAS 329216-63-9 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25N3O3SHCl and a molecular weight of 435.97 g/mol.
Based on its molecular formula C21H25N3O3SHCl, Quetiapine EP Impurity S HCl contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 435.97 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25N3O3S HCl |
| Molecular Weight | 435.97 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine Carboxylate Impurity (CAS 1011758-00-1)
- Quetiapine EP Impurity P (CAS 1011758-03-4)
- Quetiapine EP Impurity P Hemifumarate (CAS 1011758-03-4（free base）)
- Quetiapine Impurity 56 (CAS 1015-89-0)
- Quetiapine Impurity N3 (CAS 102893-57-2)
- Quetiapine-d8 HemifumarateDISCONTINUED. Please see Q510002. (CAS 1031703-36-2)
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- Quetiapine (CAS 111974-69-7)
Recommended Standards
- Vonoprazan Impurity 187 (CAS 2067322-23-8)
- Moxifloxacin Impurity 46 (CAS 141290-02-0)
- Linagliptin Impurity 90 (CAS 915226-43-6)
- Daclatasvir impurity 38 (CAS CATO-C4X-184838)
- 2-Chloro-5-methylpyridine-4-boronic acid (CAS 2377605-91-7)
- 4-(5-(4-Fluorophenyl)furan-2-yl)butan-2-amine (CAS 1484787-94-1)
- N-(3,4-Dimethylphenyl)-2-((4-ethyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618413-81-3)
- tert-butyl (2S)-2-[2-(aminooxy)ethyl]-2,3-dihydro-1H-indole-1-carboxylate (CAS 2348314-10-1)
- Netupitant Impurity 21 (CAS CATO-C4X-122321)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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